Wednesday, April 30, 2014

MIGRAINE

 Many people are talking to social media sites such as twitter to share the agony of their migraine pain, sharing the agony with other sufferers on social media indicates a trend towards the cathartic sharing of physical pain as well as emotional pain . Migraine poses a huge public health problem, harming mood, productivity and overall quality of life. An estimated 12% of the western world population suffer migraine attacks and of those 75% see reduced functionally and 30% require bed rest.

Migraine is a chronic neurological disorder characterized by repeated attacks of several headaches. A migraine headache causes throbbing and pulsating pain, usually on only one side of the head. A migraine is not simply a bad headache. A migraine is an intense headache accompanied by other symptoms such as nausea (feeling sick), visual problems and an increased sensitivity to light or sound.

The intense throbbing , pulsating pain, and excruciating pain that accompanies a migraine can be so debilitating more than 90% of sufferers are unable to work or function normally during an attack. Around two-third of adults who experience migraine is women.  About one in five women and one in ten men in the united state have experienced a migraine or severe headache in the first three months and migraine ranks as one of the top 20 most disabling medical conditions worldwide. A migraine can last up to 72 hours and the 14 million people that suffer from chronic migraines live in fear of their next attack, knowing that it can happen at any time, without warning. Although, migraines are not life threatening and do not shortens people’s life expectancies. They can significantly damage the quality of people’s lives (Migraine Research Foundation, 2013).
Types of migraine:
There are 2 types of migraine:
1)    Hemiplegic migraine:
People with hemiplegic migraine experience paralysis or weakness on one side of the body, disturbance in speech and vision, symptoms can last for several days.
a)    Familial hemiplegic migraine (FHM ):
Is an inherited genetic migraine disorder that causes hemiplegic migraine. If parents, siblings or child has FHM, the chances you will have FHM are higher.
b)    Sporadic hemiplegic migraine (SHM ):
Occur in people without the genetic disorder and without a family history of hemiplegic migraine.

2)    Ophthalmic migraine:
Also sometime called ocular or retinal migraine are rare migraine variants characterized by repeated instances of visual disturbances such as blind spots or blindness on one side of the field of vision.

Migraine Aura:
Around one in five people who experience migraine experience an aura before their attack. An aura is a warning sign that a migraine is about to happen. People commonly experience an aura between 20 minutes and one hour before the headache stage of their migraine. The main symptoms of aura are visual problems such as blurred vision (difficulty focusing), blind spots, and flashes of light or a zigzag pattern moving from the central field of vision towards the edge. Other aura symptoms include tingling sensation ( pins & needles ) in the face, lips and tongue or in the arms and legs, speech problems such as slurred speech, dizziness, a stiff neck, and a very rarely loss of consciousness.

Symptoms of Migraine:
The main symptoms of migraine are an intense throbbing or headache often affecting the front or one side of the head, nausea (feeling sick), and vomiting and increased sensitivity to light and sound. The throbbing headache is often made worse by the person moving. Other symptoms of migraine might include poor concentration, feeling hot or cold, perspiration (sweating) and increased need to pass urine. People might also experience stomach and diarrhea. It is common for people t feel tired for up to two or three days after migraine.

Migraine causes:
The exact cause of migraine is still unknown; it seems to be an electrical disturbance in the brains of people who experience an aura before their attack, there appear to be change in the blood vessels in the brain. People with high blood pressure are at a high risk of experiencing migraine. Women are more than twice as likely as men to experience migraine. This is due to hormonal factors. Women might find that they experience a migraine just before or just after the start of their periods.
Some women find that oral contraception (the pills) can trigger migraine. It might be women experience migraine as they approach the menopause or that hormone replacement therapy (HRT) triggers migraine.

Migraine triggers:
There are various factors which might trigger a migraine. Each is different and you should try to identify which factor might apply to you and try to avoid them. Many people find that they are able to that one of the triggers o is own but a combination of more than one trigger can push them over their threshold and cause an attack.
1)    Emotional triggers:
Include stress, anxiety, excitement and shock.
2)    Physical triggers:
Include tiredness, irregular sleep, tension in the neck & shoulder, eye stress (for example after using a computer screen) and dental problem (for example teeth grinding).
3)    Dietary trigger:
Include lack of food (dieting), irregular meals, dehydration, alcohol, caffeine, certain food such as chocolate, cheese, citrus fruits, certain food additives such as monosodium glutamate ( MSG ), aspartame ( a sweetener ), nitrates.
4)    Environmental triggers:
Include bright light, loud noise, and smoky environment.
5)    Other triggers:
Other triggers include smoking and some sleeping tablets.
Treatment of migraine:
1)    Most people find that lying down in a quite dark room reduces the pain of migraine.
2)    Sleeping (If you are able) can also help to treat migraine.
3)    Some people find that symptoms die down after they have vomited.
4)    Some people find that pain relief medications like paracetamol, aspirin, and anti-inflammatory drug like ibuprofen are effective, especially if they take them at the very first sign of an attack.
5)    People might also benefit from anti-sickness medications.
6)    People might be prescribed general strong pain relief medication such as Triptan which is a specific migraine medication. If situation does not improve after treatment than you might referred to a specialist migraine clinic.
 

Who is at risk for a Migraine headache?
The risk factors for migraine headache include:
1)    Age:
Most people will experience their first migraine headache before or during adolescence
2)    Family history:
Migraine headache can be hereditary. More than 75% of people who suffer from migraine headache have a parent or sibling who has migraine.
3)    Gender:
Women are three times more likely to have migraine headaches than men. Women who have migraine headaches have more frequent migraine compared to men who experience migraine.
.
      Tips to prevent Migraine:
1)    Stay on a regular sleep schedule
2)    Eat regularly
3)    Drink plenty of water to keep hydrated & trying to avoid stress
4)    Avoid food triggers such as caffeine, chocolate, cheese, alcohol, red wine.
5)    Exercise regularly
6)    Avoid stressful situations

            
NAZNEEN ZULFIQAR, PHARM-D, KU
LOWESTOFT, SUFFOLK, UNITED KINGDOM

Tuesday, April 8, 2014

FDA Advisory Panel Endorses Inhaled-Insulin Product Afrezza

A US Food and Drug Administration (FDA) advisory panel has voted in favorof MannKind's Afrezza (Technosphere insulin-inhalation system) for the treatment of both type 1 and type 2 diabetes in adults.
Votes of the Endocrinologic and Metabolic Drugs Advisory Committee in favor of Afrezza were 13-1 for type 1 diabetes and 14-0 for type 2 diabetes. One panel member left early and did not vote.
Afrezza consists of a premeal insulin powder loaded into a cartridge for oral inhalation. The company is seeking an indication as an ultrarapid-acting insulin for adults with type 1 or 2 diabetes. In type 1 patients, the indication would be for use with injected basal insulin.
Panel members cited the advantages of more rapid onset of insulin action and shorter duration, resulting in a lower risk for hypoglycemia, as well as the potential for greater acceptance of inhaled-insulin therapy for patients with type 2 diabetes who might otherwise refuse or be unable to self-inject insulin.
However, the panel did express concern about data suggesting lower glucose-lowering efficacy compared with injected short-acting insulin (aspart) in type 1 patients and about lack of long-term lung-function data beyond 2 years, as well as a possible signal for lung cancer.
Panel members presented the agency with a long list of recommendations for postmarketing studies and labeling requirements to address those issues, among others.

Risks vs Benefits
Technosphere insulin begins working within 12 to 15 minutes, peaks by 30 minutes, and is essentially cleared by 180 minutes. Current rapid-acting insulins, in contrast, peak at about 1 hour and remain in the circulation up to 5 hours.
In a pivotal trial involving 353 patients with type 2 diabetes inadequately controlled on 1 or more oral agents, Afrezza was superior to placebo in lowering HbA1c at 24 weeks, with a week-24 treatment difference of -0.40 (P< .0001). However, in a pivotal study of 344 patients with type 1 diabetes, Afrezza had significantly inferior HbA1c reduction compared with premeal injections of insulin aspart, although the difference remained within the prespecified noninferiority margin.
Rates of severe hypoglycemia were 43% lower among the type 1 patients with premeal Afrezza compared with aspart injections.
Cough was the most common adverse event, occurring in 27% of all the study subjects and leading to discontinuation in 3%. Small decrements in forced expiratory volume in 1 second (FEV1) of about 40 to 60 mL were noted within the first 3 months and persisted for the 2 years of follow-up, although there wasn't further progression.
Because of the risk for bronchospasm in patients with underlying lung disease, including chronic obstructive pulmonary disease (COPD) and asthma, the product would be contraindicated in those groups, and the label would include recommendations for screening of patients for these conditions before starting them on Afrezza and possibly for periodic ongoing monitoring of lung function as well.
A total of 4 cases of lung cancer occurred in patients who had used Afrezza, 2 during the trial in smokers, and 2 others, both squamous-cell tumors, at 2.6 and 3.8 years after the end of the trial in nonsmokers. An oncologist on the panel, Liz Szabo, MD, from the National Cancer Institute, called that "unusual" and advised that more data be collected.
Pulmonologist James K. Stoller, MD, of the Cleveland Clinic Foundation, voted yes for both type 1 and type 2 because he was "extremely impressed by the unmet need and the advantages of this drug for subsets of individuals." Nonetheless, he said he remained concerned about the potential for the product's use in patients with unrecognized COPD and expressed skepticism about the extent of adherence to a label recommendation for spirometry.
"I think we sometimes take solace that the labeling indications will inform against risk, but I am highly concerned that would not be the case in clinical practice, regardless of what it says in the label." Because of that, he advised that the contraindication include ever-smokers as well as current smokers.
Acting committee chair Robert J. Smith, MD, an endocrinologist at Brown University, Providence, Rhode Island, raised the concern that MannKind had not done a study in which Afrezza was added to basal insulin in type 2 patients, whereas basal insulin is typically introduced first in clinical practice.
Nonetheless, he also voted yes for both type 1 and type 2 patients. "Perhaps the strongest motivation for me is that an inhaled form of insulin represents a drug that will serve some patients who are not effectively served by currently available forms of insulin. I am convinced enough by the efficacy data to believe that there are at least some subgroups of patients that will substantially benefit."

However, Dr. Smith added, "I think it's quite possible that there are other subgroups, and perhaps even a majority of type 1 diabetes patients, who would do better in terms of glucose control on injected rather than this form of insulin."

He also said he voted yes because "the data about potentially serious adverse events are not strong enough that I feel it's imperative to resolve those questions before the drug might be marketed, but I think there are a number of potential concerns about adverse effects that are very, very important to follow up postmarket."

FDA advisory panel members are vetted for conflicts of interest and are given temporary waivers for participation if necessary. No waivers were issued for this meeting

Source:

Tanveer Hussain MS, IRPH
Clinical Pharmacist, VA HVHCS
Castle Point, NY

Sunday, April 6, 2014

Health Tips


BE ACTIVE.
Physical activity of at least 2½ hours a week will help you to:
1.Maintain weight
2.Reduce high blood pressure
3.Reduce risk for type 2 diabetes, heart attack, stroke, and several forms of cancer
5.Reduce arthritis pain and associated disability
6.Reduce risk for osteoporosis and falls
7.Reduce symptoms of depression and anxiety

DR I SYED.

Saturday, April 5, 2014

Health Tips



Manage stress & fatigue by:

1.Balance your work, home, and play.

2.Get support from family and friends.
3.Stay positive.
4.Take time to relax.
5.Get 7-9 hours of sleep each night. Make sure kids get more, based on their age.
6.Get help or counseling if needed.

DR I SYED.

Thursday, April 3, 2014

Health Tips

Fiber in the morning means less hunger late in the afternoon. Morning dose comes from steel-cut oatmeal, usually mixed with raisins, walnuts. An early start on eating also keeps your metabolism more active throughout the day. Remember breakfast eaters are thinner than people who just rush out the door.

DR I SYED.

Tuesday, April 1, 2014

Health Tips


Drink Cranberry Juice. Cranberries contain a substance that appears to keep bacteria from sticking to the walls of the urinary tract and has been shown to help prevent UTIs

DR I SYED.

Pharmacists

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